The accomplishments of the principals span the general areas of large-scale research planning, building multidisciplinary teams, and managing complex scientific programs.

While in government service, they developed the concepts for many new and innovative programs. They played key roles in the development of the strategic plans and legislative initiatives that authorized the creation of such important programs as Alzheimer’s Disease Centers Program, National Advisory Panel on Alzheimer’s Disease, Leadership and Excellence in Alzheimer’s Disease, Alzheimer’s Disease Education and Referral Center, and Health Services Research. They were instrumental in translating the congressional intent into programs by developing the legislative implementation plans for the National Institutes of Health. As part of the Federal Government’s annual appropriation process, they had responsibility to formulate and defend the research budgets for the Alzheimer’s disease and the Neurobiology of Aging programs.

The list of scientific programs initiated and administered by the principals include:

• Alzheimer's Disease Research Centers Program - ADRCs
• Alzheimer's Disease Patient Registry Program – CERAD
• Alzheimer’s Disease Satellite Clinics program
• Leadership and Excellence in Alzheimer’s Disease Program - LEAD
• National Research Bank for Genetic Studies of Alzheimer’s Disease
• Alzheimer’s Disease Clinical Studies Consortium (ADCS)
• Alzheimer’s Disease Drug Discoveries Program
• NIA Clinical Trial (THA/Cognex Study) on Alzheimer’s Disease The first clinical trial for the treatment of Alzheimer’s disease
• Initiative to Standardize International Clinical Trials for Alzheimer’s Disease
• Diagnostics for Alzheimer’s Disease - National and international efforts to standardize diagnostic instruments and to develop diagnostic criteria for clinical practice research neuropathological evaluation and international epidemiological studies of Alzheimer's disease
• Multi-site International Collaborative Studies on Epidemiology of Alzheimer’s Disease as a joint NIA - WHO project
• The Office of Alzheimer' Disease Research, which served as the NIH Alzheimer’s Disease Research Coordinating Committee
• The Ronald and Nancy Reagan Research Institute of the Alzheimer’s Association
• The International Society for Alzheimer’s Disease Research
• KWIK REVIEW SYSTEM (Software for Grants Application, Review & Management)
• Consensus development Work Groups (Think-Tanks)

The principals are recognized as prominent national and international spokespeople on all scientific matters relating to Alzheimer’s disease and the aging brain. They routinely comment and interpret results of scientific reports for the media as well as for lay audiences. Many of their activities include helping major print and television reporters, writers, and producers in preparing articles and TV programs on Alzheimer’s disease. In addition, they are expert at identifying key scientific issues and people to be interviewed, explaining the significance of scientific breakthroughs, preparing reports, briefings, and technical information.

The KRA principals continue to make original scientific contributions by writing theoretical articles, editorials, review articles, chapters and editing books. In addition they maintain a busy schedule of public speaking engagements with various audiences.